4bpc

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{{STRUCTURE_4bpc| PDB=4bpc | SCENE= }}
 
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===Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form===
 
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{{ABSTRACT_PUBMED_23820885}}
 
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==Function==
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==Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form==
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[[http://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.
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<StructureSection load='4bpc' size='340' side='right'caption='[[4bpc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpc OCA], [https://pdbe.org/4bpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpc RCSB], [https://www.ebi.ac.uk/pdbsum/4bpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein tyrosine phosphatase sigma (PTPsigma) plays a vital role in neural development. The extracellular domain of PTPsigma binds to various proteoglycans, which control the activity of 2 intracellular PTP domains (D1 and D2). To understand the regulatory mechanism of PTPsigma, we carried out structural and biochemical analyses of PTPsigma D1D2. In the crystal structure analysis of a mutant form of D1D2 of PTPsigma, we unexpectedly found that the catalytic cysteine of D1 is oxidized to cysteine sulfenic acid, while that of D2 remained in its reduced form, suggesting that D1 is more sensitive to oxidation than D2. This finding contrasts previous observations on PTPalpha. The cysteine sulfenic acid of D1 was further confirmed by immunoblot and mass spectrometric analyses. The stabilization of the cysteine sulfenic acid in the active site of PTP suggests that the formation of cysteine sulfenic acid may function as a stable intermediate during the redox-regulation of PTPs.
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==About this Structure==
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Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form.,Jeon TJ, Chien PN, Chun HJ, Ryu SE Mol Cells. 2013 May 30. PMID:23820885<ref>PMID:23820885</ref>
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[[4bpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023820885</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4bpc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Chien, P N.]]
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[[Category: Chien PN]]
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[[Category: Chun, H J.]]
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[[Category: Chun HJ]]
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[[Category: Jeon, T J.]]
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[[Category: Jeon TJ]]
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[[Category: Ryu, S E.]]
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[[Category: Ryu SE]]
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[[Category: Hydrolase]]
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[[Category: Proteoglycan]]
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[[Category: Redox regulation]]
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Current revision

Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form

PDB ID 4bpc

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