4l4v

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{{STRUCTURE_4l4v| PDB=4l4v | SCENE= }}
 
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===Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH===
 
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==Disease==
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==Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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<StructureSection load='4l4v' size='340' side='right'caption='[[4l4v]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l4v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VY:1-DEOXY-1-(7-HYDROXY-6-METHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>1VY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4v OCA], [https://pdbe.org/4l4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4v RCSB], [https://www.ebi.ac.uk/pdbsum/4l4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid and an agonist ligand derived from a riboflavin metabolite. For both vitamin B antigens, the MAIT TCR docks in a conserved manner above MR1, thus acting as an innate-like pattern recognition receptor. The invariant MAIT TCR alpha-chain usage is attributable to MR1-mediated interactions that prise open the MR1 cleft to allow contact with the vitamin B metabolite. Although the non-stimulatory antigen does not contact the MAIT TCR, the stimulatory antigen does. This results in a higher affinity of the MAIT TCR for a stimulatory antigen in comparison with a non-stimulatory antigen. We formally demonstrate a structural basis for MAIT TCR recognition of vitamin B metabolites, while illuminating how TCRs recognize microbial metabolic signatures.
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==Function==
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Recognition of vitamin B metabolites by mucosal-associated invariant T cells.,Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142. PMID:23846752<ref>PMID:23846752</ref>
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[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4l4v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4V OCA].
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</div>
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<div class="pdbe-citations 4l4v" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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<references group="xtra"/><references/>
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beddoe, T.]]
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[[Category: Large Structures]]
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[[Category: Birkinshaw, R W.]]
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[[Category: Beddoe T]]
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[[Category: Brooks, A G.]]
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[[Category: Birkinshaw RW]]
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[[Category: Chen, Z.]]
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[[Category: Brooks AG]]
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[[Category: Corbett, A J.]]
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[[Category: Chen Z]]
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[[Category: Eckle, S B.G.]]
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[[Category: Corbett AJ]]
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[[Category: Fairlie, D P.]]
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[[Category: Eckle SBG]]
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[[Category: Kjer-Nielsen, L.]]
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[[Category: Fairlie DP]]
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[[Category: Liu, L.]]
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[[Category: Kjer-Nielsen L]]
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[[Category: McCluskey, J.]]
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[[Category: Le Nours J]]
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[[Category: Meehan, B.]]
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[[Category: Liu L]]
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[[Category: Miles, J J.]]
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[[Category: McCluskey J]]
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[[Category: Nours, J Le.]]
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[[Category: Meehan B]]
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[[Category: Patel, O.]]
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[[Category: Miles JJ]]
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[[Category: Reantragoon, R.]]
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[[Category: Patel O]]
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[[Category: Rossjohn, J.]]
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[[Category: Reantragoon R]]
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[[Category: Sandoval-Romero, M L.]]
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[[Category: Rossjohn J]]
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[[Category: Sullivan, L C.]]
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[[Category: Sandoval-Romero ML]]
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[[Category: Immune system]]
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[[Category: Sullivan LC]]
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[[Category: Mait tcr]]
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[[Category: Membrane protein-immune system complex]]
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[[Category: Mhc class i-related protein]]
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[[Category: Vitamin b metabolite]]
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Current revision

Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH

PDB ID 4l4v

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