2ob9

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{{STRUCTURE_2ob9| PDB=2ob9 | SCENE= }}
 
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===Structure of bacteriophage HK97 tail assembly chaperone===
 
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{{ABSTRACT_PUBMED_23542344}}
 
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==About this Structure==
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==Structure of bacteriophage HK97 tail assembly chaperone==
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[[2ob9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_hk97 Enterobacteria phage hk97]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OB9 OCA].
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<StructureSection load='2ob9' size='340' side='right'caption='[[2ob9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ob9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_HK97 Escherichia virus HK97]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OB9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ob9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ob9 OCA], [https://pdbe.org/2ob9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ob9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ob9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ob9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9MCS5_BPHK7 Q9MCS5_BPHK7]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2ob9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ob9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tail assembly chaperones (TACs) are a family of proteins likely required for the morphogenesis of all long-tailed phages. In this study, we determined the crystal structure of gp13, the TAC of phage HK97. This structure is similar to that of the TAC from the Lactococcus phage p2 and two unannotated structures of likely TACs encoded in prophage-derived regions of Bacillus subtilis and Bacillus stearothermophilus. Despite the high sequence divergence of these proteins, gp13 forms a ring structure with similar dimensions to the spirals observed in the crystal lattices of these other proteins. Remarkably, these similar quaternary structures are formed through very different interprotomer interactions. We present functional data supporting the biological relevance of these spiral structures and propose that spiral formation has been the primary requirement for these proteins during evolution. This study presents an unusual example of diverged protein sequences and oligomerization mechanisms in the presence of conserved quaternary structure.
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==Reference==
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A Conserved Spiral Structure for Highly Diverged Phage Tail Assembly Chaperones.,Pell LG, Cumby N, Clark TE, Tuite A, Battaile KP, Edwards AM, Chirgadze NY, Davidson AR, Maxwell KL J Mol Biol. 2013 Mar 28. pii: S0022-2836(13)00202-7. doi:, 10.1016/j.jmb.2013.03.035. PMID:23542344<ref>PMID:23542344</ref>
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<ref group="xtra">PMID:023542344</ref><references group="xtra"/><references/>
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[[Category: Enterobacteria phage hk97]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Bona, D.]]
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</div>
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[[Category: Chirgadze, N Y.]]
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<div class="pdbe-citations 2ob9" style="background-color:#fffaf0;"></div>
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[[Category: Edwards, A M.]]
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== References ==
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[[Category: Maxwell, K.]]
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<references/>
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[[Category: McGrath, T E.]]
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__TOC__
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[[Category: Saridakis, V.]]
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</StructureSection>
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[[Category: Tuite, A.]]
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[[Category: Escherichia virus HK97]]
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[[Category: Bacteriophage hk97]]
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[[Category: Large Structures]]
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[[Category: Chaperone]]
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[[Category: Bona D]]
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[[Category: Morphogenesis]]
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[[Category: Chirgadze NY]]
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[[Category: Tail assembly chaperone]]
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[[Category: Edwards AM]]
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[[Category: Maxwell K]]
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[[Category: McGrath TE]]
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[[Category: Saridakis V]]
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[[Category: Tuite A]]

Current revision

Structure of bacteriophage HK97 tail assembly chaperone

PDB ID 2ob9

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