2dpr

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{{STRUCTURE_2dpr| PDB=2dpr | SCENE= }}
 
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===The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif===
 
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{{ABSTRACT_PUBMED_17243678}}
 
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==Function==
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==The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif==
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[[http://www.uniprot.org/uniprot/CKT_CONTU CKT_CONTU]] Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice.<ref>PMID:2165278</ref>
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<StructureSection load='2dpr' size='340' side='right'caption='[[2dpr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2dpr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_tulipa Conus tulipa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DPR FirstGlance]. <br>
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[[2dpr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPR OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dpr OCA], [https://pdbe.org/2dpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dpr RCSB], [https://www.ebi.ac.uk/pdbsum/2dpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dpr ProSAT]</span></td></tr>
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<ref group="xtra">PMID:017243678</ref><references group="xtra"/><references/>
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</table>
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[[Category: Castellino, F J.]]
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== Function ==
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[[Category: Cnudde, S E.]]
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[https://www.uniprot.org/uniprot/CKT_CONTU CKT_CONTU] Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice.<ref>PMID:2165278</ref>
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[[Category: Dai, Q.]]
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== References ==
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[[Category: Geiger, J H.]]
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<references/>
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[[Category: Prorok, M.]]
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__TOC__
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[[Category: Con-t]]
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</StructureSection>
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[[Category: Conantoxin]]
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[[Category: Conus tulipa]]
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[[Category: Gla-containing]]
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[[Category: Large Structures]]
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[[Category: Metal binding protein]]
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[[Category: Castellino FJ]]
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[[Category: Nmdar antagonist]]
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[[Category: Cnudde SE]]
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[[Category: Dai Q]]
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[[Category: Geiger JH]]
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[[Category: Prorok M]]

Current revision

The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif

PDB ID 2dpr

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