4j8s

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{{STRUCTURE_4j8s| PDB=4j8s | SCENE= }}
 
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===Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide===
 
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{{ABSTRACT_PUBMED_23644599}}
 
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==Function==
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==Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide==
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[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/TTP_HUMAN TTP_HUMAN]] mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).<ref>PMID:15014438</ref>
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<StructureSection load='4j8s' size='340' side='right'caption='[[4j8s]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4j8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J8S FirstGlance]. <br>
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[[4j8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8S OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j8s OCA], [https://pdbe.org/4j8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j8s RCSB], [https://www.ebi.ac.uk/pdbsum/4j8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j8s ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023644599</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blackshear, P J.]]
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[[Category: Large Structures]]
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[[Category: Fabian, M R.]]
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[[Category: Blackshear PJ]]
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[[Category: Frank, F.]]
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[[Category: Fabian MR]]
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[[Category: Karetnikov, A.]]
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[[Category: Frank F]]
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[[Category: Lai, W S.]]
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[[Category: Karetnikov A]]
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[[Category: Nagar, B.]]
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[[Category: Lai WS]]
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[[Category: Rouya, C.]]
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[[Category: Nagar B]]
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[[Category: Siddiqui, N.]]
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[[Category: Rouya C]]
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[[Category: Sonenberg, N.]]
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[[Category: Siddiqui N]]
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[[Category: Cytosol]]
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[[Category: Sonenberg N]]
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[[Category: Mif4g]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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[[Category: Ttp]]
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Current revision

Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide

PDB ID 4j8s

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