4joi
From Proteopedia
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| - | {{STRUCTURE_4joi| PDB=4joi | SCENE= }} | ||
| - | ===Crystal structure of the human telomeric Stn1-Ten1 complex=== | ||
| - | {{ABSTRACT_PUBMED_23826127}} | ||
| - | == | + | ==Crystal structure of the human telomeric Stn1-Ten1 complex== |
| - | [[ | + | <StructureSection load='4joi' size='340' side='right'caption='[[4joi]], [[Resolution|resolution]] 2.05Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4joi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JOI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4joi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4joi OCA], [https://pdbe.org/4joi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4joi RCSB], [https://www.ebi.ac.uk/pdbsum/4joi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4joi ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | <ref | + | == Function == |
| + | [https://www.uniprot.org/uniprot/STN1_HUMAN STN1_HUMAN] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.<ref>PMID:19854130</ref> <ref>PMID:19648609</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bryan | + | [[Category: Large Structures]] |
| - | [[Category: Harkisheimer | + | [[Category: Bryan C]] |
| - | [[Category: Rice | + | [[Category: Harkisheimer M]] |
| - | [[Category: Schultz | + | [[Category: Rice C]] |
| - | [[Category: Skordalakes | + | [[Category: Schultz D]] |
| - | + | [[Category: Skordalakes E]] | |
| - | + | ||
Current revision
Crystal structure of the human telomeric Stn1-Ten1 complex
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