4jk4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:44, 20 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4jk4| PDB=4jk4 | SCENE= }}
 
-
===Crystal Structure of Bovine Serum Albumin in complex with 3,5-diiodosalicylic acid===
 
-
{{ABSTRACT_PUBMED_23769932}}
 
-
==Function==
+
==Crystal Structure of Bovine Serum Albumin in complex with 3,5-diiodosalicylic acid==
-
[[http://www.uniprot.org/uniprot/ALBU_BOVIN ALBU_BOVIN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
+
<StructureSection load='4jk4' size='340' side='right'caption='[[4jk4]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4jk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JK4 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.653&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DIU:2-HYDROXY-3,5-DIIODO-BENZOIC+ACID'>DIU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jk4 OCA], [https://pdbe.org/4jk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4jk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jk4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ALBU_BOVIN ALBU_BOVIN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Due to their extraordinary binding properties, serum albumins are the main transporters of many small molecules in the circulatory system. Although all mammalian serum albumins exhibit quite high sequence similarity, their binding abilities are not the same. Until now, only human serum albumin (HSA) was subjected to extensive structural studies in complexes with various ligands. Here we present two crystal structures of the complexes of equine and bovine serum albumins with 3,5-diiodosalicylic acid (DIS), at resolutions 2.12A and 2.65A, respectively, and analyze interactions of the DIS ligand with both macromolecules. We highlight the differences in distribution of DIS binding sites between the bovine and equine serum albumins and compare results with the HSA binding ability of DIS and other structurally similar ligands.
-
==About this Structure==
+
Crystallographic studies of the complexes of bovine and equine serum albumin with 3,5-diiodosalicylic acid.,Sekula B, Zielinski K, Bujacz A Int J Biol Macromol. 2013 Jun 12;60C:316-324. doi:, 10.1016/j.ijbiomac.2013.06.004. PMID:23769932<ref>PMID:23769932</ref>
-
[[4jk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK4 OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:023769932</ref><references group="xtra"/><references/>
+
</div>
 +
<div class="pdbe-citations 4jk4" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Albumin 3D structures|Albumin 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Bujacz, A.]]
+
[[Category: Large Structures]]
-
[[Category: Bujacz, G.]]
+
[[Category: Bujacz A]]
-
[[Category: Sekula, B.]]
+
[[Category: Bujacz G]]
-
[[Category: Zielinski, K.]]
+
[[Category: Sekula B]]
-
[[Category: Bovine serum albumin]]
+
[[Category: Zielinski K]]
-
[[Category: Fatty acid]]
+
-
[[Category: Helical protein possessing three domain]]
+
-
[[Category: Hormone]]
+
-
[[Category: Metabolites and drug]]
+
-
[[Category: Plasma]]
+
-
[[Category: Transport]]
+
-
[[Category: Transport protein]]
+

Current revision

Crystal Structure of Bovine Serum Albumin in complex with 3,5-diiodosalicylic acid

PDB ID 4jk4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4jk4"
Personal tools