2m3s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:58, 15 May 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_2m3s| PDB=2m3s | SCENE= }}
 
-
===Calmodulin, i85l, f92e, h107i, l107i, a128t, m144r mutant===
 
-
{{ABSTRACT_PUBMED_23630096}}
 
-
==Function==
+
==Calmodulin, i85l, f92e, h107i, l112r, a128t, m144r mutant==
-
[[http://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
+
<StructureSection load='2m3s' size='340' side='right'caption='[[2m3s]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2m3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3S FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3s OCA], [https://pdbe.org/2m3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3s RCSB], [https://www.ebi.ac.uk/pdbsum/2m3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3s ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CALM_CHICK CALM_CHICK] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
It only takes one mutation: A strategically placed single mutation in a non-enzymatic protein scaffold produced AlleyCat, a small, allosterically regulated catalyst of Kemp elimination. In only seven rounds of directed evolution the enzymatic efficiency of the original 74 amino acid residue catalyst was improved more than 220-fold to achieve a kcat value higher than that of catalytic antibodies for the same reaction, still preserving allosteric regulation.
-
==About this Structure==
+
A single mutation in a regulatory protein produces evolvable allosterically regulated catalyst of nonnatural reaction.,Moroz OV, Moroz YS, Wu Y, Olsen AB, Cheng H, Mack KL, McLaughlin JM, Raymond EA, Zhezherya K, Roder H, Korendovych IV Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6246-9. doi: 10.1002/anie.201302339., Epub 2013 Apr 29. PMID:23630096<ref>PMID:23630096</ref>
-
[[2m3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3S OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:023630096</ref><references group="xtra"/><references/>
+
</div>
 +
<div class="pdbe-citations 2m3s" style="background-color:#fffaf0;"></div>
 +
 
 +
==See Also==
 +
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
-
[[Category: Cheng, H.]]
+
[[Category: Large Structures]]
-
[[Category: Korendovych, I V.]]
+
[[Category: Cheng H]]
-
[[Category: Moroz, Y S.]]
+
[[Category: Korendovych IV]]
-
[[Category: Roder, H.]]
+
[[Category: Moroz YS]]
-
[[Category: Wu, Y.]]
+
[[Category: Roder H]]
-
[[Category: Calmodulin]]
+
[[Category: Wu Y]]
-
[[Category: Metal binding protein]]
+

Current revision

Calmodulin, i85l, f92e, h107i, l112r, a128t, m144r mutant

PDB ID 2m3s

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m3s"
Personal tools