3wcy

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{{STRUCTURE_3wcy| PDB=3wcy | SCENE= }}
 
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===Murine Ifnar1 in complex with interferon-beta===
 
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==Function==
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==Murine Ifnar1 in complex with interferon-beta==
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[[http://www.uniprot.org/uniprot/INAR1_MOUSE INAR1_MOUSE]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [[http://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE]] Has antiviral, antibacterial and anticancer activities.
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<StructureSection load='3wcy' size='340' side='right'caption='[[3wcy]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3wcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcy OCA], [https://pdbe.org/3wcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wcy RCSB], [https://www.ebi.ac.uk/pdbsum/3wcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INAR1_MOUSE INAR1_MOUSE] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
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==About this Structure==
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==See Also==
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[[3wcy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCY OCA].
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*[[Interferon 3D structures|Interferon 3D structures]]
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*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hertzog, P J.]]
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[[Category: Hertzog PJ]]
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[[Category: Rossjohn, J.]]
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[[Category: Rossjohn J]]
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[[Category: Vivian, J P.]]
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[[Category: Vivian JP]]
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[[Category: Weerd, N A.de.]]
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[[Category: De Weerd NA]]
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[[Category: Cytokine receptor]]
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[[Category: Cytokine receptor-cytokine complex]]
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[[Category: Fibronectin type iii]]
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[[Category: Helical cytokine]]
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[[Category: Interferon]]
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Current revision

Murine Ifnar1 in complex with interferon-beta

PDB ID 3wcy

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