2izr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:30, 13 December 2023) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2izr.gif|left|200px]]<br /><applet load="2izr" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2izr, resolution 1.30&Aring;" />
 
-
'''STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR'''<br />
 
-
==About this Structure==
+
==Structure of casein kinase gamma 3 in complex with inhibitor==
-
2IZR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=BRK:'>BRK</scene> and <scene name='pdbligand=PGO:'>PGO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Known structural/functional Site: <scene name='pdbsite=AC1:Pgo+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZR OCA].
+
<StructureSection load='2izr' size='340' side='right'caption='[[2izr]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Non-specific serine/threonine protein kinase]]
+
<table><tr><td colspan='2'>[[2izr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZR FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-
[[Category: Arrowsmith, C.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRK:{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE'>BRK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
-
[[Category: Bunkoczi, G.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izr OCA], [https://pdbe.org/2izr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izr RCSB], [https://www.ebi.ac.uk/pdbsum/2izr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izr ProSAT]</span></td></tr>
-
[[Category: Das, S.]]
+
</table>
-
[[Category: Debreczeni, J E.]]
+
== Function ==
-
[[Category: Delft, F Von.]]
+
[https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
-
[[Category: Edwards, A.]]
+
== Evolutionary Conservation ==
-
[[Category: Fedorov, O.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Gileadi, O.]]
+
Check<jmol>
-
[[Category: Knapp, S.]]
+
<jmolCheckbox>
-
[[Category: Rellos, P.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/2izr_consurf.spt"</scriptWhenChecked>
-
[[Category: Salah, E.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Savitsky, P.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Sundstrom, M.]]
+
</jmolCheckbox>
-
[[Category: Weigelt, J.]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2izr ConSurf].
-
[[Category: BRK]]
+
<div style="clear:both"></div>
-
[[Category: CL]]
+
-
[[Category: MG]]
+
-
[[Category: PGO]]
+
-
[[Category: alternative splicing]]
+
-
[[Category: atp-binding]]
+
-
[[Category: kinase]]
+
-
[[Category: nucleotide-binding]]
+
-
[[Category: phosphorylation]]
+
-
[[Category: serine/threonine kinase]]
+
-
[[Category: serine/threonine-protein kinase]]
+
-
[[Category: transferase]]
+
-
[[Category: wnt signaling pathway]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:44 2008''
+
==See Also==
 +
*[[Casein kinase 3D structures|Casein kinase 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith C]]
 +
[[Category: Bunkoczi G]]
 +
[[Category: Das S]]
 +
[[Category: Debreczeni JE]]
 +
[[Category: Edwards A]]
 +
[[Category: Fedorov O]]
 +
[[Category: Gileadi O]]
 +
[[Category: Knapp S]]
 +
[[Category: Rellos P]]
 +
[[Category: Salah E]]
 +
[[Category: Savitsky P]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Weigelt J]]
 +
[[Category: Von Delft F]]

Current revision

Structure of casein kinase gamma 3 in complex with inhibitor

PDB ID 2izr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2izr"
Personal tools