3w01

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{{STRUCTURE_3w01| PDB=3w01 | SCENE= }}
 
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===Crystal structure of PcrB complexed with PEG from Staphylococcus aureus subsp. aureus Mu3===
 
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{{ABSTRACT_PUBMED_23322418}}
 
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==Function==
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==Crystal structure of PcrB complexed with PEG from Staphylococcus aureus subsp. aureus Mu3==
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[[http://www.uniprot.org/uniprot/PCRB_STAA1 PCRB_STAA1]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity).
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<StructureSection load='3w01' size='340' side='right'caption='[[3w01]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w01]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu3 Staphylococcus aureus subsp. aureus Mu3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W01 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w01 OCA], [https://pdbe.org/3w01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w01 RCSB], [https://www.ebi.ac.uk/pdbsum/3w01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w01 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCRB_STAA1 PCRB_STAA1] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Well structured: As a new triose phosphate isomerase (TIM) barrel-fold prenyl transferase, PcrB catalyzes the production of heptaprenylglyceryl phosphate from heptaprenyl diphosphate and glycerol-1-phosphate. Crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus in complex with ligands were solved, and together with site-directed mutagenesis and bioinformatics analyses, clearly reveal the catalytic mechanism of the enzyme.
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==About this Structure==
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Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus.,Ren F, Feng X, Ko TP, Huang CH, Hu Y, Chan HC, Liu YL, Wang K, Chen CC, Pang X, He M, Li Y, Oldfield E, Guo RT Chembiochem. 2013 Jan 21;14(2):195-9. doi: 10.1002/cbic.201200748. Epub 2013 Jan , 15. PMID:23322418<ref>PMID:23322418</ref>
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[[3w01]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu3 Staphylococcus aureus subsp. aureus mu3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W01 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023322418</ref><references group="xtra"/><references/>
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</div>
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[[Category: Staphylococcus aureus subsp. aureus mu3]]
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<div class="pdbe-citations 3w01" style="background-color:#fffaf0;"></div>
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[[Category: Chan, H C.]]
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== References ==
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[[Category: Chen, C C.]]
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<references/>
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[[Category: Feng, X.]]
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__TOC__
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[[Category: Guo, R T.]]
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</StructureSection>
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[[Category: He, M.]]
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[[Category: Large Structures]]
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[[Category: Hu, Y.]]
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[[Category: Staphylococcus aureus subsp. aureus Mu3]]
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[[Category: Huang, C H.]]
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[[Category: Chan HC]]
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[[Category: Ko, T P.]]
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[[Category: Chen CC]]
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[[Category: Li, Y.]]
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[[Category: Feng X]]
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[[Category: Liu, Y L.]]
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[[Category: Guo RT]]
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[[Category: Oldfield, E.]]
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[[Category: He M]]
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[[Category: Pang, X.]]
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[[Category: Hu Y]]
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[[Category: Ren, F.]]
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[[Category: Huang CH]]
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[[Category: Wang, K.]]
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[[Category: Ko TP]]
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[[Category: Biosynthesis]]
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[[Category: Li Y]]
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[[Category: Enzyme catalysis]]
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[[Category: Liu YL]]
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[[Category: Prenyltransferase]]
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[[Category: Oldfield E]]
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[[Category: Transferase]]
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[[Category: Pang X]]
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[[Category: Ren F]]
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[[Category: Wang K]]

Current revision

Crystal structure of PcrB complexed with PEG from Staphylococcus aureus subsp. aureus Mu3

PDB ID 3w01

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