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| - | {{STRUCTURE_4fds| PDB=4fds | SCENE= }}
| + | #REDIRECT [[4mz6]] This PDB entry is obsolete and replaced by 4mz6 |
| - | ===Structure of importin-alpha: dUTPase S11E NLS mutant complex===
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/IMA2_MOUSE IMA2_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref> | + | |
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| - | ==About this Structure==
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| - | [[4fds]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDS OCA].
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| - | ==Reference==
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| - | <references group="xtra"/><references/>
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| - | [[Category: Mus musculus]]
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| - | [[Category: DUTP diphosphatase]]
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| - | [[Category: Kobe, B.]]
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| - | [[Category: Marfori, M.]]
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| - | [[Category: Rona, G.]]
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| - | [[Category: Vertessy, B G.]]
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| - | [[Category: Arm repeat]]
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| - | [[Category: Cse1]]
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| - | [[Category: Importin beta]]
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| - | [[Category: Nuclear localisation signal]]
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| - | [[Category: Nucleo-cytoplasmic]]
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| - | [[Category: Nup2/ nup50]]
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| - | [[Category: Protein transport]]
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| - | [[Category: Protein transport-hydrolase complex]]
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Current revision
- REDIRECT 4mz6 This PDB entry is obsolete and replaced by 4mz6
