4gca

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{{STRUCTURE_4gca| PDB=4gca | SCENE= }}
 
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===Complex of Aldose Reductase with inhibitor IDD 1219===
 
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==Function==
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==Complex of Aldose Reductase with inhibitor IDD 1219==
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[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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<StructureSection load='4gca' size='340' side='right'caption='[[4gca]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GCA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2X9:{2,6-DIMETHYL-5-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]PYRIDIN-3-YL}ACETIC+ACID'>2X9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gca OCA], [https://pdbe.org/4gca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gca RCSB], [https://www.ebi.ac.uk/pdbsum/4gca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gca ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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==About this Structure==
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==See Also==
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[[4gca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCA OCA].
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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[[Category: Aldehyde reductase]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Geraci, L S.]]
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[[Category: Large Structures]]
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[[Category: Podjarny, A D.]]
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[[Category: Geraci LS]]
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[[Category: Zandt, M Van.]]
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[[Category: Podjarny AD]]
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[[Category: Oxidoreductase]]
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[[Category: Van Zandt M]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim barrel]]
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Current revision

Complex of Aldose Reductase with inhibitor IDD 1219

PDB ID 4gca

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