This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ksb
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_4ksb| PDB=4ksb | SCENE= }} | ||
| - | ===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain=== | ||
| - | == | + | ==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain== |
| - | [[ | + | <StructureSection load='4ksb' size='340' side='right'caption='[[4ksb]], [[Resolution|resolution]] 3.80Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4ksb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSB FirstGlance]. <br> |
| - | [[4ksb]] is a 1 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8001Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksb OCA], [https://pdbe.org/4ksb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksb RCSB], [https://www.ebi.ac.uk/pdbsum/4ksb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksb ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Caya A]] | |
| - | [[Category: Caya | + | [[Category: Chang G]] |
| - | [[Category: Chang | + | [[Category: Cregger C]] |
| - | [[Category: Cregger | + | [[Category: Doshi R]] |
| - | [[Category: Doshi | + | [[Category: Falson P]] |
| - | [[Category: Falson | + | [[Category: Govaerts C]] |
| - | [[Category: Govaerts | + | [[Category: Grimard V]] |
| - | [[Category: Grimard | + | [[Category: Lee C-W]] |
| - | [[Category: Lee | + | [[Category: Martinez L]] |
| - | [[Category: Martinez | + | [[Category: Pardon E]] |
| - | [[Category: Pardon | + | [[Category: Steyaert J]] |
| - | [[Category: Steyaert | + | [[Category: Swartz DJ]] |
| - | [[Category: Swartz | + | [[Category: Szewczyk P]] |
| - | [[Category: Szewczyk | + | [[Category: Urbatsch I]] |
| - | [[Category: Urbatsch | + | [[Category: Villaluz M]] |
| - | [[Category: Villaluz | + | [[Category: Ward A]] |
| - | [[Category: Ward | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
| |||||||||||
Categories: Large Structures | Mus musculus | Caya A | Chang G | Cregger C | Doshi R | Falson P | Govaerts C | Grimard V | Lee C-W | Martinez L | Pardon E | Steyaert J | Swartz DJ | Szewczyk P | Urbatsch I | Villaluz M | Ward A
