4ldr

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{{STRUCTURE_4ldr| PDB=4ldr | SCENE= }}
 
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===Structure of the S283Y mutant of MRDI===
 
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{{ABSTRACT_PUBMED_23859498}}
 
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==Function==
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==Structure of the S283Y mutant of MRDI==
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[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
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<StructureSection load='4ldr' size='340' side='right'caption='[[4ldr]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4ldr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDR FirstGlance]. <br>
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[[4ldr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDR OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.292&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldr OCA], [https://pdbe.org/4ldr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldr RCSB], [https://www.ebi.ac.uk/pdbsum/4ldr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldr ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023859498</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: S-methyl-5-thioribose-1-phosphate isomerase]]
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[[Category: Large Structures]]
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[[Category: Metzner, S I.]]
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[[Category: Metzner SI]]
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[[Category: Sousa, M C.]]
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[[Category: Sousa MC]]
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[[Category: Templeton, P D.]]
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[[Category: Templeton PD]]
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[[Category: Cell invasion]]
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[[Category: Helix bundle]]
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[[Category: Isomerase]]
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[[Category: Rossmann-like fold]]
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Current revision

Structure of the S283Y mutant of MRDI

PDB ID 4ldr

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