2jbz

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[[Image:2jbz.gif|left|200px]]<br /><applet load="2jbz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2jbz, resolution 1.62&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE STREPTOMYCES COELICOLOR HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE (ACPS) IN COMPLEX WITH COENZYME A AT 1.6 A'''<br />
 
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==About this Structure==
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==Crystal structure of the Streptomyces coelicolor holo-[Acyl-carrier-protein] Synthase (AcpS) in complex with coenzyme A at 1.6 A==
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2JBZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=COA:'>COA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Holo-[acyl-carrier-protein]_synthase Holo-[acyl-carrier-protein] synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.7 2.7.8.7] Known structural/functional Site: <scene name='pdbsite=AC1:Coa+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBZ OCA].
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<StructureSection load='2jbz' size='340' side='right'caption='[[2jbz]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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[[Category: Holo-[acyl-carrier-protein] synthase]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2jbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBZ FirstGlance]. <br>
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[[Category: Streptomyces coelicolor]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
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[[Category: Aglio, P Dall.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Arthur, C.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbz OCA], [https://pdbe.org/2jbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbz RCSB], [https://www.ebi.ac.uk/pdbsum/2jbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbz ProSAT]</span></td></tr>
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[[Category: Crosby, J.]]
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</table>
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[[Category: Crump, M P.]]
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== Function ==
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[[Category: Hadfield, A T.]]
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[https://www.uniprot.org/uniprot/ACPS_STRCO ACPS_STRCO] Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.[HAMAP-Rule:MF_00101]
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[[Category: Law, C K.E.]]
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== Evolutionary Conservation ==
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[[Category: COA]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: K]]
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Check<jmol>
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[[Category: MG]]
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<jmolCheckbox>
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[[Category: acp]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbz_consurf.spt"</scriptWhenChecked>
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[[Category: acyl carrier protein synthase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: coenzyme a]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: fatty acid biosynthesis]]
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</jmolCheckbox>
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[[Category: lipid synthesis]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jbz ConSurf].
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[[Category: magnesium]]
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<div style="clear:both"></div>
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[[Category: metal-binding]]
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[[Category: phosphopantetheine arm]]
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[[Category: poliketides]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:01:31 2008''
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==See Also==
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*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptomyces coelicolor]]
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[[Category: Arthur C]]
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[[Category: Crosby J]]
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[[Category: Crump MP]]
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[[Category: Dall'Aglio P]]
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[[Category: Hadfield AT]]
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[[Category: Law CKE]]

Current revision

Crystal structure of the Streptomyces coelicolor holo-[Acyl-carrier-protein] Synthase (AcpS) in complex with coenzyme A at 1.6 A

PDB ID 2jbz

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