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4j7e

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{{STRUCTURE_4j7e| PDB=4j7e | SCENE= }}
 
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===The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529===
 
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{{ABSTRACT_PUBMED_14704432}}
 
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==Function==
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==The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529==
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[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
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<StructureSection load='4j7e' size='340' side='right'caption='[[4j7e]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I29:[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2,4,5-TRIMETHYL-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]{4-[3-(METHYLSULFONYL)PROPYL]PIPERAZIN-1-YL}METHANONE'>I29</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7e OCA], [https://pdbe.org/4j7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7e RCSB], [https://www.ebi.ac.uk/pdbsum/4j7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
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==About this Structure==
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==See Also==
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[[4j7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7E OCA].
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*[[MDM2 3D structures|MDM2 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014704432</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Graves, B.]]
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[[Category: Graves B]]
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[[Category: Janson, C.]]
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[[Category: Janson C]]
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[[Category: Lukacs, C.]]
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[[Category: Lukacs C]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: Imidazoline]]
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[[Category: Ligase-antagonist complex]]
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[[Category: Mdm2]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Protein-protein interaction]]
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Current revision

The 1.63A crystal structure of humanized Xenopus MDM2 with a nutlin fragment, RO5524529

PDB ID 4j7e

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