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4li1

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{{STRUCTURE_4li1| PDB=4li1 | SCENE= }}
 
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===Crystal Structures of Lgr4 and its complex with R-spondin1===
 
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{{ABSTRACT_PUBMED_23891289}}
 
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==Function==
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==Crystal Structures of Lgr4 and its complex with R-spondin1==
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[[http://www.uniprot.org/uniprot/LGR4_XENTR LGR4_XENTR]] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.
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<StructureSection load='4li1' size='340' side='right'caption='[[4li1]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4li1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LI1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.658&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4li1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4li1 OCA], [https://pdbe.org/4li1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4li1 RCSB], [https://www.ebi.ac.uk/pdbsum/4li1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4li1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LGR4_XENTR LGR4_XENTR] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The leucine-rich repeat-containing G-protein-coupled receptors (Lgrs) are a large membrane protein family mediating signaling events during development and in the adult organism. Type 2 Lgrs, including Lgr4, Lgr5, and Lgr6, play crucial roles in embryonic development and in several cancers. They also regulate adult stem cell maintenance via direct association with proteins in the Wnt signaling pathways, including Lrp5/6 and frizzled receptors. The R-spondins (Rspo) were recently identified as functional ligands for type 2 Lgrs and were shown to synergize with both canonical and noncanonical Wnt signaling pathways. We determined and report the structure of the Lgr4 ectodomain alone and bound to Rspo1. The structures reveal an extended horseshoe leucine-rich repeat (LRR) receptor architecture that binds, with its concave side, the ligand furin-like repeats via an intimate interface. The molecular details of ligand/receptor recognition provide insight into receptor activation and could serve as template for stem-cell-based regenerative therapeutics development.
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==About this Structure==
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Crystal Structures of Lgr4 and Its Complex with R-Spondin1.,Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB Structure. 2013 Jul 23. pii: S0969-2126(13)00242-6. doi:, 10.1016/j.str.2013.07.001. PMID:23891289<ref>PMID:23891289</ref>
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[[4li1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI1 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023891289</ref><references group="xtra"/><references/>
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</div>
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[[Category: Rajashankar, K.]]
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<div class="pdbe-citations 4li1" style="background-color:#fffaf0;"></div>
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[[Category: Robev, D.]]
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== References ==
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[[Category: Xu, Y.]]
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<references/>
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[[Category: Hormone receptor]]
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__TOC__
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[[Category: Lrr]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Xenopus tropicalis]]
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[[Category: Rajashankar K]]
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[[Category: Robev D]]
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[[Category: Xu Y]]

Current revision

Crystal Structures of Lgr4 and its complex with R-spondin1

PDB ID 4li1

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