4fox

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{{STRUCTURE_4fox| PDB=4fox | SCENE= }}
 
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===Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed===
 
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==Function==
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==Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed==
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[[http://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
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<StructureSection load='4fox' size='340' side='right'caption='[[4fox]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fox]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FOX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D16:TOMUDEX'>D16</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fox OCA], [https://pdbe.org/4fox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fox RCSB], [https://www.ebi.ac.uk/pdbsum/4fox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fox ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
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==About this Structure==
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==See Also==
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[[4fox]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FOX OCA].
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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[[Category: Mycobacterium tuberculosis h37rv]]
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__TOC__
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[[Category: Thymidylate synthase]]
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</StructureSection>
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[[Category: Bruning, J B.]]
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[[Category: Large Structures]]
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[[Category: Harshbarger, W.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Reddy, M C.M.]]
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[[Category: Bruning JB]]
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[[Category: Sacchettini, J C.]]
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[[Category: Harshbarger W]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Reddy MCM]]
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[[Category: Structural genomic]]
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[[Category: Sacchettini JC]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Thymidylate synthase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed

PDB ID 4fox

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