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UvrABC

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[[Image:3pih.png|left|200px|thumb|Crystal structure of UvrA complex with DNA, pyrophosphate and Zn+2 ion [[3pih]]]]
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<StructureSection load='3pih' size='340' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='53/536710/Cv/3' >
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{{STRUCTURE_3pih| PDB=3pih | SIZE=400| SCENE= |right|CAPTION= UvrA complex with DNA, pyrophosphate and Zn+2 ion [[3pih]] }}
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== Function ==
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'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br />
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* '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br />
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* '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br />
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* The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>.
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* '''UvrD''' is '''DNA helicase II'''. See [[Helicase]].
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For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]].
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== Structural highlights ==
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UvrA contains several domains: <scene name='53/536710/Cv/2'>UvrB-binding, DNA-binding and two ATP-binding domains</scene><ref>PMID:21240268</ref>.
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'''UvrABC''' endonuclease is an E. coli enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one. For details on the UvrA-UvrB complex see [[UvrA-UvrB interaction domains]].
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==3D structures of UvrABC==
==3D structures of UvrABC==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[UvrABC 3D structures]]
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===UvrA===
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[[3pih]] – TmUvrA + DNA – ''Thermotoga maritima'' <br />
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[[3zqj]] – UvrA – ''Mycobacterium tuberculosis''<br />
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[[4dfc]] – EcUvrA + Transcription-repair-coupling factor – ''Escherichia coli'' <br />
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[[2r6f]] – BstUvrA – ''Bacillus stearothermophilus'' <br />
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[[3ux8]] – GeUvrA - ''Geobacillus''<br />
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===UvrB===
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[[1d2m]], [[1c4o]] – UvrB – ''Thermus thermophilus'' <br />
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[[1d9x]] – BcUvrB – ''Bacillus caldotenax'' <br />
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[[1t5l]] – BcUvrB (mutant) <br />
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[[1qoj]] – EcUvrB C terminal <br />
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[[1e52]] – EcUvrB C terminal - NMR<br />
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[[1d9z]] – BcUvrB + ATP <br />
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[[2fdc]] – BcUvrB + DNA <br />
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[[2d7d]], [[2nmv]], [[3v4r]] – BsUvrB + DNA – ''Bacillus subtilis'' <br />
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===UvrC===
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[[1kft]] – EcUvrC C terminal <br />
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[[2nrr]], [[2nrt]], [[2nrv]], [[2nrw]], [[2nrx]], [[2nrz]] – TmUvrC C terminal <br />
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[[1ycz]], [[1yd0]], [[1yd1]] – TmUvrC N terminal <br />
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[[1yd2]], [[1yd3]], [[1yd4]], [[1yd5]] – TmUvrC N terminal (mutant)<br />
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[[1yd6]] – BcUvrC N terminal <br />
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[[3c65]] – BstUvrC <br />
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===UvrA-UvrB===
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[[3fpn]] – BstUvrA + UvrB <br />
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[[3uwx]] – GeUvrA + UvrB <br />
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==References==
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<references />
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) 3pih

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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