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2mbv

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(New page: '''Unreleased structure''' The entry 2mbv is ON HOLD Authors: Joseph, S., Matthews, J.M., Kwan, A.H.-Y., Mackay, J.P., Cubeddu, L., Foo, P. Description: LMO4-LIM2 in complex with DEAF-...)
Current revision (06:59, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2mbv is ON HOLD
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==LMO4-LIM2 in complex with DEAF1 (404-418)==
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<StructureSection load='2mbv' size='340' side='right'caption='[[2mbv]]' scene=''>
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Authors: Joseph, S., Matthews, J.M., Kwan, A.H.-Y., Mackay, J.P., Cubeddu, L., Foo, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2mbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBV FirstGlance]. <br>
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Description: LMO4-LIM2 in complex with DEAF-1 (404-418)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbv OCA], [https://pdbe.org/2mbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbv RCSB], [https://www.ebi.ac.uk/pdbsum/2mbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LMO4_MOUSE LMO4_MOUSE] Probable transcriptional factor.[https://www.uniprot.org/uniprot/DEAF1_MOUSE DEAF1_MOUSE] Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior (PubMed:24726472).[UniProtKB:O75398]<ref>PMID:14966286</ref> <ref>PMID:18826651</ref> <ref>PMID:19668219</ref> <ref>PMID:24726472</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Cubeddu L]]
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[[Category: Foo P]]
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[[Category: Joseph S]]
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[[Category: Kwan AH-Y]]
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[[Category: Mackay JP]]
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[[Category: Matthews JM]]

Current revision

LMO4-LIM2 in complex with DEAF1 (404-418)

PDB ID 2mbv

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