4le8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Als3 adhesin from Candida albicans, residues 1-299 (mature sequence)== | |
| - | + | <StructureSection load='4le8' size='340' side='right'caption='[[4le8]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4le8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LE8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4le8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4le8 OCA], [https://pdbe.org/4le8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4le8 RCSB], [https://www.ebi.ac.uk/pdbsum/4le8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4le8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALS3_CANAL ALS3_CANAL] Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.<ref>PMID:15128742</ref> <ref>PMID:15256583</ref> <ref>PMID:16839200</ref> <ref>PMID:17510860</ref> <ref>PMID:18635358</ref> <ref>PMID:22321066</ref> <ref>PMID:22429754</ref> <ref>PMID:22544909</ref> <ref>PMID:23630968</ref> <ref>PMID:24152214</ref> <ref>PMID:24736223</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Candida albicans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cota E]] | ||
| + | [[Category: Garnett JA]] | ||
| + | [[Category: Lin J]] | ||
Current revision
Structure of the Als3 adhesin from Candida albicans, residues 1-299 (mature sequence)
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