4m3g
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4m3g is ON HOLD Authors: Villemagne, B., Flipo, M., Blondiaux, N., Crauste, C., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Brodin, P., Vi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches== | |
| + | <StructureSection load='4m3g' size='340' side='right'caption='[[4m3g]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4m3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M3G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2G1:4-(2-METHYL-1,3-THIAZOL-4-YL)-N-(3,3,3-TRIFLUOROPROPYL)BENZENESULFONAMIDE'>2G1</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3g OCA], [https://pdbe.org/4m3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m3g RCSB], [https://www.ebi.ac.uk/pdbsum/4m3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m3g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Baulard A]] | ||
| + | [[Category: Blondiaux N]] | ||
| + | [[Category: Brodin P]] | ||
| + | [[Category: Crauste C]] | ||
| + | [[Category: Deprez B]] | ||
| + | [[Category: Flipo M]] | ||
| + | [[Category: Leroux F]] | ||
| + | [[Category: Malaquin S]] | ||
| + | [[Category: Piveteau C]] | ||
| + | [[Category: Sperandio O]] | ||
| + | [[Category: Villemagne B]] | ||
| + | [[Category: Villeret V]] | ||
| + | [[Category: Villoutreix B]] | ||
| + | [[Category: Willand N]] | ||
| + | [[Category: Wintjens R]] | ||
| + | [[Category: Wohlkonig A]] | ||
Current revision
Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches
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