4m4e

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(New page: '''Unreleased structure''' The entry 4m4e is ON HOLD Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J. Description: An adaptor protein)
Current revision (14:41, 8 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4m4e is ON HOLD
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==TRAF domain of human TRAF4==
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<StructureSection load='4m4e' size='340' side='right'caption='[[4m4e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4m4e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M4E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m4e OCA], [https://pdbe.org/4m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m4e RCSB], [https://www.ebi.ac.uk/pdbsum/4m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m4e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TRAF4 is a unique member of TRAF family, which is essential for innate immune response, nervous system and other systems. In addition to be an adaptor protein, TRAF4 was identified as a regulator protein in recent studies. We have determined the crystal structure of TRAF domain of TRAF4 (residues 292-466) at 2.60 A resolution by X-ray crystallography method. The trimericly assembled TRAF4 resembles a mushroom shape, containing a super helical "stalk" which is made of three right-handed intertwined alpha helixes and a C-terminal "cap", which is divided at residue L302 as a boundary. Similar to other TRAFs, both intermolecular hydrophobic interaction in super helical "stalk" and hydrogen bonds in "cap" regions contribute directly to the formation of TRAF4 trimer. However, differing from other TRAFs, there is an additional flexible loop (residues 421-426), which contains a previously identified phosphorylated site S426 exposing on the surface. This S426 was reported to be phosphorylated by IKKalpha which is the pre-requisite for TRAF4-NOD2 complex formation and thus to inhibit NOD2-induced NF-kappaB activation. Therefore, the crystal structure of TRAF4-TRAF is valuable for understanding its molecular basis for its special function and provides structural information for further studies.
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Authors: Niu, F., Ru, H., Ding, W., Ouyang, S., Liu, Z.J.
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Structural biology study of human TNF receptor associated factor 4 TRAF domain.,Niu F, Ru H, Ding W, Ouyang S, Liu ZJ Protein Cell. 2013 Aug 27. PMID:23982741<ref>PMID:23982741</ref>
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Description: An adaptor protein
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4m4e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ding W]]
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[[Category: Liu ZJ]]
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[[Category: Niu F]]
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[[Category: Ouyang S]]
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[[Category: Ru H]]

Current revision

TRAF domain of human TRAF4

PDB ID 4m4e

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