4gvj
From Proteopedia
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| - | {{STRUCTURE_4gvj| PDB=4gvj | SCENE= }} | ||
| - | ===Tyk2 (JH1) in complex with adenosine di-phosphate=== | ||
| - | {{ABSTRACT_PUBMED_23867602}} | ||
| - | == | + | ==Tyk2 (JH1) in complex with adenosine di-phosphate== |
| - | [[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN | + | <StructureSection load='4gvj' size='340' side='right'caption='[[4gvj]], [[Resolution|resolution]] 2.03Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GVJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gvj OCA], [https://pdbe.org/4gvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gvj RCSB], [https://www.ebi.ac.uk/pdbsum/4gvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gvj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Abbema | + | [[Category: Abbema AV]] |
| - | [[Category: Bao | + | [[Category: Bao L]] |
| - | [[Category: Barrett | + | [[Category: Barrett K]] |
| - | [[Category: Beresini | + | [[Category: Beresini M]] |
| - | [[Category: Berezhkovskiy | + | [[Category: Berezhkovskiy L]] |
| - | [[Category: Blair | + | [[Category: Blair W]] |
| - | [[Category: Chang | + | [[Category: Chang C]] |
| - | [[Category: Driscoll | + | [[Category: Driscoll J]] |
| - | [[Category: Eigenbrot | + | [[Category: Eigenbrot C]] |
| - | [[Category: Ghilardi | + | [[Category: Ghilardi N]] |
| - | [[Category: Gibbons | + | [[Category: Gibbons P]] |
| - | [[Category: Halladay | + | [[Category: Halladay J]] |
| - | [[Category: Johnson | + | [[Category: Johnson A]] |
| - | [[Category: Kohli | + | [[Category: Kohli PB]] |
| - | [[Category: Lai | + | [[Category: Lai Y]] |
| - | [[Category: Liang | + | [[Category: Liang J]] |
| - | [[Category: Liimatta | + | [[Category: Liimatta M]] |
| - | [[Category: Magnuson | + | [[Category: Magnuson S]] |
| - | [[Category: Mantik | + | [[Category: Mantik P]] |
| - | [[Category: Menghrajani | + | [[Category: Menghrajani K]] |
| - | [[Category: Murray | + | [[Category: Murray J]] |
| - | [[Category: Sambrone | + | [[Category: Sambrone A]] |
| - | [[Category: Shao | + | [[Category: Shao Y]] |
| - | [[Category: Shia | + | [[Category: Shia S]] |
| - | [[Category: Shin | + | [[Category: Shin Y]] |
| - | [[Category: Smith | + | [[Category: Smith J]] |
| - | [[Category: Sohn | + | [[Category: Sohn S]] |
| - | [[Category: Stanley | + | [[Category: Stanley M]] |
| - | [[Category: Tsui | + | [[Category: Tsui V]] |
| - | [[Category: Ultsch | + | [[Category: Ultsch M]] |
| - | [[Category: Wu | + | [[Category: Wu L]] |
| - | [[Category: Zhang | + | [[Category: Zhang B]] |
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Current revision
Tyk2 (JH1) in complex with adenosine di-phosphate
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Categories: Homo sapiens | Large Structures | Abbema AV | Bao L | Barrett K | Beresini M | Berezhkovskiy L | Blair W | Chang C | Driscoll J | Eigenbrot C | Ghilardi N | Gibbons P | Halladay J | Johnson A | Kohli PB | Lai Y | Liang J | Liimatta M | Magnuson S | Mantik P | Menghrajani K | Murray J | Sambrone A | Shao Y | Shia S | Shin Y | Smith J | Sohn S | Stanley M | Tsui V | Ultsch M | Wu L | Zhang B
