4guq

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{{STRUCTURE_4guq| PDB=4guq | SCENE= }}
 
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===Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element===
 
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{{ABSTRACT_PUBMED_23892287}}
 
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==Function==
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==Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element==
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[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
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<StructureSection load='4guq' size='340' side='right'caption='[[4guq]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4guq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4guq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guq OCA], [https://pdbe.org/4guq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guq RCSB], [https://www.ebi.ac.uk/pdbsum/4guq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
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==About this Structure==
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==See Also==
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[[4guq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUQ OCA].
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*[[P73|P73]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023892287</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ethayathulla, A S.]]
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[[Category: Large Structures]]
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[[Category: Nguyen, H T.]]
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[[Category: Ethayathulla AS]]
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[[Category: Viadiu, H.]]
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[[Category: Nguyen HT]]
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[[Category: Beta-immunoglobulin]]
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[[Category: Viadiu H]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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[[Category: Tumor suppressor]]
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Current revision

Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element

PDB ID 4guq

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