4isq

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{{STRUCTURE_4isq| PDB=4isq | SCENE= }}
 
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===Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I===
 
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==Function==
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==Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I==
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[[http://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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<StructureSection load='4isq' size='340' side='right'caption='[[4isq]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4isq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ISQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4isq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isq OCA], [https://pdbe.org/4isq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4isq RCSB], [https://www.ebi.ac.uk/pdbsum/4isq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9LBR1_CLOBO Q9LBR1_CLOBO]
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==About this Structure==
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==See Also==
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[[4isq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISQ OCA].
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Berntsson, R P.A.]]
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[[Category: Homo sapiens]]
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[[Category: Dong, M.]]
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[[Category: Large Structures]]
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[[Category: Peng, L.]]
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[[Category: Berntsson RP-A]]
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[[Category: Stenmark, P.]]
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[[Category: Dong M]]
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[[Category: Svensson, L M.]]
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[[Category: Peng L]]
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[[Category: Membrane binding]]
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[[Category: Stenmark P]]
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[[Category: Synaptotagmin and ganglioside binding]]
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[[Category: Svensson LM]]
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[[Category: Toxin]]
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Current revision

Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I

PDB ID 4isq

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