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2jpe
From Proteopedia
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| - | [[Image:2jpe.jpg|left|200px]]<br /><applet load="2jpe" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jpe" /> | ||
| - | '''FHA domain of NIPP1'''<br /> | ||
| - | == | + | ==FHA domain of NIPP1== |
| - | + | <StructureSection load='2jpe' size='340' side='right'caption='[[2jpe]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2jpe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JPE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpe OCA], [https://pdbe.org/2jpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jpe RCSB], [https://www.ebi.ac.uk/pdbsum/2jpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jpe ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PP1R8_MOUSE PP1R8_MOUSE] Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development.<ref>PMID:15501817</ref> <ref>PMID:15199142</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/2jpe_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jpe ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Fujioka Y]] | |
| - | [[Category: Fujioka | + | [[Category: Inagaki F]] |
| - | [[Category: Inagaki | + | [[Category: Kikuchi K]] |
| - | [[Category: Kikuchi | + | [[Category: Kumeta H]] |
| - | [[Category: Kumeta | + | [[Category: Ogura K]] |
| - | [[Category: Ogura | + | [[Category: Tanuma N]] |
| - | [[Category: Tanuma | + | |
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Current revision
FHA domain of NIPP1
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Categories: Large Structures | Mus musculus | Fujioka Y | Inagaki F | Kikuchi K | Kumeta H | Ogura K | Tanuma N
