2ynx
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| - | {{STRUCTURE_2ynx| PDB=2ynx | SCENE= }} | ||
| - | ===Crystal Structure of Ancestral Thioredoxin Relative to Last Archaea Common Ancestor (LACA) from the Precambrian Period=== | ||
| - | {{ABSTRACT_PUBMED_23932589}} | ||
| - | == | + | ==Crystal Structure of Ancestral Thioredoxin Relative to Last Archaea Common Ancestor (LACA) from the Precambrian Period== |
| - | [[2ynx]] is a 2 chain structure with sequence from [ | + | <StructureSection load='2ynx' size='340' side='right'caption='[[2ynx]], [[Resolution|resolution]] 1.75Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ynx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YNX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.749Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ynx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ynx OCA], [https://pdbe.org/2ynx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ynx RCSB], [https://www.ebi.ac.uk/pdbsum/2ynx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ynx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Little is known about the evolution of protein structures and the degree of protein structure conservation over planetary time scales. Here, we report the X-ray crystal structures of seven laboratory resurrections of Precambrian thioredoxins dating up to approximately four billion years ago. Despite considerable sequence differences compared with extant enzymes, the ancestral proteins display the canonical thioredoxin fold, whereas only small structural changes have occurred over four billion years. This remarkable degree of structure conservation since a time near the last common ancestor of life supports a punctuated-equilibrium model of structure evolution in which the generation of new folds occurs over comparatively short periods and is followed by long periods of structural stasis. | ||
| - | + | Conservation of Protein Structure over Four Billion Years.,Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA Structure. 2013 Aug 6. pii: S0969-2126(13)00244-X. doi:, 10.1016/j.str.2013.06.020. PMID:23932589<ref>PMID:23932589</ref> | |
| - | <ref | + | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2ynx" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Thioredoxin 3D structures|Thioredoxin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Synthetic construct]] | [[Category: Synthetic construct]] | ||
| - | + | [[Category: Gavira JA]] | |
| - | [[Category: Gavira | + | [[Category: Ibarra-Molero B]] |
| - | [[Category: Ibarra-Molero | + | [[Category: Ingles-Prieto A]] |
| - | [[Category: Ingles-Prieto | + | [[Category: Sanchez-Ruiz JM]] |
| - | [[Category: Sanchez-Ruiz | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of Ancestral Thioredoxin Relative to Last Archaea Common Ancestor (LACA) from the Precambrian Period
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