4kg4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:12, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4kg4| PDB=4kg4 | SCENE= }}
 
-
===Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain (E198Q mutation)===
 
-
{{ABSTRACT_PUBMED_23911090}}
 
-
==Function==
+
==Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain (E198Q mutation)==
-
[[http://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref>
+
<StructureSection load='4kg4' size='340' side='right'caption='[[4kg4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[4kg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KG4 FirstGlance]. <br>
-
[[4kg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG4 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg4 OCA], [https://pdbe.org/4kg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kg4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg4 ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
<ref group="xtra">PMID:023911090</ref><references group="xtra"/><references/>
+
== Function ==
-
[[Category: Saccharomyces cerevisiae s288c]]
+
[https://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref>
-
[[Category: Aglietti, R A.]]
+
== References ==
-
[[Category: Floor, S N.]]
+
<references/>
-
[[Category: Gross, J D.]]
+
__TOC__
-
[[Category: Hydrolase]]
+
</StructureSection>
-
[[Category: Mrna decapping]]
+
[[Category: Large Structures]]
-
[[Category: Mrna decay]]
+
[[Category: Saccharomyces cerevisiae S288C]]
-
[[Category: Nudix]]
+
[[Category: Aglietti RA]]
 +
[[Category: Floor SN]]
 +
[[Category: Gross JD]]

Current revision

Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain (E198Q mutation)

PDB ID 4kg4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kg4"
Personal tools