2jw5
From Proteopedia
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| - | [[Image:2jw5.jpg|left|200px]]<br /><applet load="2jw5" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jw5" /> | ||
| - | '''Polymerase Lambda BRCT domain'''<br /> | ||
| - | == | + | ==Polymerase Lambda BRCT domain== |
| - | + | <StructureSection load='2jw5' size='340' side='right'caption='[[2jw5]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2jw5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JW5 FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw5 OCA], [https://pdbe.org/2jw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw5 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw5 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/2jw5_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [[ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jw5 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
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| - | + | ==See Also== | |
| + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: DeRose EF]] | ||
| + | [[Category: London RE]] | ||
| + | [[Category: Moon AF]] | ||
| + | [[Category: Mueller GA]] | ||
| + | [[Category: Pedersen LC]] | ||
Current revision
Polymerase Lambda BRCT domain
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