4k6e

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{{STRUCTURE_4k6e| PDB=4k6e | SCENE= }}
 
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===Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg===
 
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{{ABSTRACT_PUBMED_23911090}}
 
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==Function==
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==Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg==
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[[http://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref>
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<StructureSection load='4k6e' size='340' side='right'caption='[[4k6e]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4k6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K6E FirstGlance]. <br>
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[[4k6e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6E OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6e OCA], [https://pdbe.org/4k6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k6e RCSB], [https://www.ebi.ac.uk/pdbsum/4k6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6e ProSAT]</span></td></tr>
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<ref group="xtra">PMID:023911090</ref><references group="xtra"/><references/>
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</table>
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[[Category: Saccharomyces cerevisiae s288c]]
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== Function ==
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[[Category: Aglietti, R A.]]
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[https://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref>
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[[Category: Floor, S N.]]
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== References ==
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[[Category: Gross, J D.]]
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<references/>
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[[Category: Hydrolase]]
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__TOC__
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[[Category: Mrna decapping]]
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</StructureSection>
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[[Category: Nudix]]
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[[Category: Large Structures]]
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[[Category: Nudix hydrolase]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Aglietti RA]]
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[[Category: Floor SN]]
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[[Category: Gross JD]]

Current revision

Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg

PDB ID 4k6e

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