4l9u

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{{STRUCTURE_4l9u| PDB=4l9u | SCENE= }}
 
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===Structure of C-terminal coiled coil of RasGRP1===
 
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{{ABSTRACT_PUBMED_23908768}}
 
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==Disease==
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==Structure of C-terminal coiled coil of RasGRP1==
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[[http://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
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<StructureSection load='4l9u' size='340' side='right'caption='[[4l9u]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4l9u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9U FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN]] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6014&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9u OCA], [https://pdbe.org/4l9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9u RCSB], [https://www.ebi.ac.uk/pdbsum/4l9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9u ProSAT]</span></td></tr>
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[[4l9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
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<ref group="xtra">PMID:023908768</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barros, T.]]
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[[Category: Large Structures]]
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[[Category: Che, Y.]]
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[[Category: Barros T]]
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[[Category: Das, R.]]
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[[Category: Che Y]]
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[[Category: Iwig, J S.]]
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[[Category: Das R]]
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[[Category: Kuriyan, J.]]
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[[Category: Iwig JS]]
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[[Category: Limnander, A.]]
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[[Category: Kuriyan J]]
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[[Category: Pelton, J G.]]
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[[Category: Limnander A]]
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[[Category: Roose, J P.]]
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[[Category: Pelton JG]]
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[[Category: Vercoulen, Y.]]
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[[Category: Roose JP]]
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[[Category: Wemmer, D E.]]
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[[Category: Vercoulen Y]]
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[[Category: Signaling protein]]
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[[Category: Wemmer DE]]

Current revision

Structure of C-terminal coiled coil of RasGRP1

PDB ID 4l9u

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