3wg6
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_3wg6| PDB=3wg6 | SCENE= }} | ||
| - | ===Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH=== | ||
| - | {{ABSTRACT_PUBMED_23852710}} | ||
| - | == | + | ==Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH== |
| - | [[3wg6]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3wg6' size='340' side='right'caption='[[3wg6]], [[Resolution|resolution]] 2.20Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3wg6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg6 OCA], [https://pdbe.org/3wg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg6 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CPRC1_CANPA CPRC1_CANPA] NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. Reduces ketopantoyl lactone (2-dehydropantolactone) and isatin. Does not act on menadione, p-nitrobenzaldehyde and pyridine-3-aldehyde.<ref>PMID:11826979</ref> <ref>PMID:14593510</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 is a member of the aldo-keto reductase (AKR) superfamily and reduces ketopantoyl lactone to D-pantoyl lactone in a NADPH-dependent and stereospecific manner. We determined the crystal structure of CPR-C1.NADPH complex at 2.20 A resolution. CPR-C1 adopted a triose-phosphate isomerase (TIM) barrel fold at the core of the structure in which Thr25 and Lys26 of the GXGTX motif bind uniquely to the adenosine 2'-phosphate group of NADPH. This finding provides a novel structural basis for NADPH binding of the AKR superfamily. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc. | ||
| - | + | Crystal structure of conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 complexed with NADPH.,Qin HM, Yamamura A, Miyakawa T, Kataoka M, Maruoka S, Ohtsuka J, Nagata K, Shimizu S, Tanokura M Proteins. 2013 Jul 15. doi: 10.1002/prot.24363. PMID:23852710<ref>PMID:23852710</ref> | |
| - | <ref | + | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3wg6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Candida parapsilosis]] | [[Category: Candida parapsilosis]] | ||
| - | [[Category: Kataoka | + | [[Category: Large Structures]] |
| - | [[Category: Maruoka | + | [[Category: Kataoka M]] |
| - | [[Category: Miyakawa | + | [[Category: Maruoka S]] |
| - | [[Category: Nagata | + | [[Category: Miyakawa T]] |
| - | [[Category: Ohtsuka | + | [[Category: Nagata K]] |
| - | [[Category: Qin | + | [[Category: Ohtsuka J]] |
| - | [[Category: Shimizu | + | [[Category: Qin H-M]] |
| - | [[Category: Tanokura | + | [[Category: Shimizu S]] |
| - | [[Category: Yamamura | + | [[Category: Tanokura M]] |
| - | + | [[Category: Yamamura A]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of conjugated polyketone reductase C1 from Candida parapsilosis complexed with NADPH
| |||||||||||
Categories: Candida parapsilosis | Large Structures | Kataoka M | Maruoka S | Miyakawa T | Nagata K | Ohtsuka J | Qin H-M | Shimizu S | Tanokura M | Yamamura A
