2jx1
From Proteopedia
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| - | [[Image:2jx1.gif|left|200px]]<br /><applet load="2jx1" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jx1" /> | ||
| - | '''Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA'''<br /> | ||
| - | == | + | ==Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA== |
| - | + | <StructureSection load='2jx1' size='340' side='right'caption='[[2jx1]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2jx1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JX1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jx1 OCA], [https://pdbe.org/2jx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2jx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jx1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MYT1_MOUSE MYT1_MOUSE] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).<ref>PMID:9373037</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jx1_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jx1 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Gamsjaeger R]] | |
| - | [[Category: Gamsjaeger | + | [[Category: Kobus FJ]] |
| - | [[Category: Kobus | + | [[Category: Kwan AH]] |
| - | [[Category: Kwan | + | [[Category: Lehtomaki E]] |
| - | [[Category: Lehtomaki | + | [[Category: Lowry JA]] |
| - | [[Category: Lowry | + | [[Category: Mackay JP]] |
| - | [[Category: Mackay | + | [[Category: Matthews JM]] |
| - | [[Category: Matthews | + | [[Category: Swanton MK]] |
| - | [[Category: Swanton | + | |
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Current revision
Structure of the fifth zinc finger of Myelin Transcription Factor 1 in complex with RARE DNA
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Categories: Large Structures | Mus musculus | Gamsjaeger R | Kobus FJ | Kwan AH | Lehtomaki E | Lowry JA | Mackay JP | Matthews JM | Swanton MK
