4kq6
From Proteopedia
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| - | {{STRUCTURE_4kq6| PDB=4kq6 | SCENE= }} | ||
| - | ===Product complex of lumazine synthase from candida glabrata=== | ||
| - | {{ABSTRACT_PUBMED_23897480}} | ||
| - | == | + | ==Product complex of lumazine synthase from candida glabrata== |
| - | [[4kq6]] is a 10 chain structure with sequence from [ | + | <StructureSection load='4kq6' size='340' side='right'caption='[[4kq6]], [[Resolution|resolution]] 2.24Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kq6]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gef 4gef]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQ6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLZ:1-DEOXY-1-(6,7-DIMETHYL-2,4-DIOXO-3,4-DIHYDROPTERIDIN-8(2H)-YL)-D-RIBITOL'>DLZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq6 OCA], [https://pdbe.org/4kq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kq6 RCSB], [https://www.ebi.ac.uk/pdbsum/4kq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q6FXA8_CANGA Q6FXA8_CANGA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 A resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction. | ||
| - | + | Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.,Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1580-6. doi:, 10.1107/S0907444913010949. Epub 2013 Jul 20. PMID:23897480<ref>PMID:23897480</ref> | |
| - | <ref | + | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Monk | + | <div class="pdbe-citations 4kq6" style="background-color:#fffaf0;"></div> |
| - | [[Category: Nakatani | + | == References == |
| - | [[Category: Shankar | + | <references/> |
| - | [[Category: Tyndall | + | __TOC__ |
| - | [[Category: Wilbanks | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Monk BC]] | |
| - | + | [[Category: Nakatani Y]] | |
| + | [[Category: Shankar M]] | ||
| + | [[Category: Tyndall JDA]] | ||
| + | [[Category: Wilbanks SM]] | ||
Current revision
Product complex of lumazine synthase from candida glabrata
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