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4hhr

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{{STRUCTURE_4hhr| PDB=4hhr | SCENE= }}
 
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===Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)===
 
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{{ABSTRACT_PUBMED_23373518}}
 
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==Function==
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==Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)==
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[[http://www.uniprot.org/uniprot/DOX1_ARATH DOX1_ARATH]] Alpha-dioxygenase that catalyzes the primary oxygenation of fatty acids into oxylipins. Mediates a protection against oxidative stress and cell death, probably by generating some lipid-derived molecules. Promotes local and systemic plant defense in a salicylic acid (SA)-dependent manner, including the establishment of systemic acquired resistance (SAR) in response to incompatible interaction. Involved in a negative regulation of abscisic acid (ABA)-mediated signaling pathway.<ref>PMID:12060227</ref> <ref>PMID:10455113</ref> <ref>PMID:22199234</ref>
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<StructureSection load='4hhr' size='340' side='right'caption='[[4hhr]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4hhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HHR FirstGlance]. <br>
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[[4hhr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHR OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhr OCA], [https://pdbe.org/4hhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hhr RCSB], [https://www.ebi.ac.uk/pdbsum/4hhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhr ProSAT]</span></td></tr>
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<ref group="xtra">PMID:023373518</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOX1_ARATH DOX1_ARATH] Alpha-dioxygenase that catalyzes the primary oxygenation of fatty acids into oxylipins. Mediates a protection against oxidative stress and cell death, probably by generating some lipid-derived molecules. Promotes local and systemic plant defense in a salicylic acid (SA)-dependent manner, including the establishment of systemic acquired resistance (SAR) in response to incompatible interaction. Involved in a negative regulation of abscisic acid (ABA)-mediated signaling pathway.<ref>PMID:12060227</ref> <ref>PMID:10455113</ref> <ref>PMID:22199234</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Goulah, C C.]]
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[[Category: Large Structures]]
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[[Category: Koszelak-Rosenblum, M.]]
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[[Category: Goulah CC]]
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[[Category: Malkowski, M G.]]
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[[Category: Koszelak-Rosenblum M]]
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[[Category: Zhu, G.]]
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[[Category: Malkowski MG]]
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[[Category: Calcium binding]]
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[[Category: Zhu G]]
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[[Category: Cyclooxygenase myeloperoxidase folding]]
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[[Category: Fatty acid dioxygenase]]
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[[Category: Monotopic membrane protein]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of fatty acid alpha-dioxygenase (Arabidopsis thaliana)

PDB ID 4hhr

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