3uxo
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| - | {{STRUCTURE_3uxo| PDB=3uxo | SCENE= }} | ||
| - | ===Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme=== | ||
| - | {{ABSTRACT_PUBMED_23651085}} | ||
| - | == | + | ==Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme== |
| - | [[http://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT | + | <StructureSection load='3uxo' size='340' side='right'caption='[[3uxo]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3uxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UXO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uxo OCA], [https://pdbe.org/3uxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uxo RCSB], [https://www.ebi.ac.uk/pdbsum/3uxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uxo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. | ||
==See Also== | ==See Also== | ||
| - | *[[DNA polymerase|DNA polymerase]] | + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Gridley | + | [[Category: Gridley CL]] |
| - | [[Category: Jaeger | + | [[Category: Jaeger J]] |
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Current revision
Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme
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