3j3r

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{{STRUCTURE_3j3r| PDB=3j3r | SCENE= }}
 
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===Structural dynamics of the MecA-ClpC complex revealed by cryo-EM===
 
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{{ABSTRACT_PUBMED_23595989}}
 
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==Function==
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==Structural dynamics of the MecA-ClpC complex revealed by cryo-EM==
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[[http://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU]] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref> [[http://www.uniprot.org/uniprot/CLPC_BACSU CLPC_BACSU]] Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.
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<SX load='3j3r' size='340' side='right' viewer='molstar' caption='[[3j3r]], [[Resolution|resolution]] 9.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3j3r]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J3R FirstGlance]. <br>
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[[3j3r]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J3R OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j3r OCA], [https://pdbe.org/3j3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j3r RCSB], [https://www.ebi.ac.uk/pdbsum/3j3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j3r ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:023595989</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/MECA1_BACSU MECA1_BACSU] Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.<ref>PMID:12598648</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Gao, N.]]
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[[Category: Large Structures]]
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[[Category: Lei, J.]]
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[[Category: Gao N]]
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[[Category: Li, N.]]
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[[Category: Lei J]]
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[[Category: Liu, J.]]
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[[Category: Li N]]
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[[Category: Mei, Z.]]
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[[Category: Liu J]]
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[[Category: Qi, Y.]]
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[[Category: Mei Z]]
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[[Category: Shi, Y.]]
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[[Category: Qi Y]]
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[[Category: Wang, F.]]
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[[Category: Shi Y]]
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[[Category: Xu, Y.]]
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[[Category: Wang F]]
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[[Category: Aaa+ atpase]]
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[[Category: Xu Y]]
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[[Category: Chaperone]]
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[[Category: Clpc]]
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[[Category: Meca]]
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[[Category: Protein unfolding]]
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Current revision

Structural dynamics of the MecA-ClpC complex revealed by cryo-EM

3j3r, resolution 9.40Å

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OCA

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