4j8f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:02, 1 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4j8f| PDB=4j8f | SCENE= }}
 
-
===Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip===
 
-
{{ABSTRACT_PUBMED_23812373}}
 
-
==About this Structure==
+
==Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip==
-
[[4j8f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8F OCA].
+
<StructureSection load='4j8f' size='340' side='right'caption='[[4j8f]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4j8f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J8F FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j8f OCA], [https://pdbe.org/4j8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j8f RCSB], [https://www.ebi.ac.uk/pdbsum/4j8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j8f ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HS71A_HUMAN HS71A_HUMAN] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).<ref>PMID:16537599</ref> <ref>PMID:22528486</ref> <ref>PMID:23973223</ref> [https://www.uniprot.org/uniprot/F10A1_RAT F10A1_RAT] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
==See Also==
==See Also==
-
*[[Heat Shock Proteins|Heat Shock Proteins]]
+
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:023812373</ref><references group="xtra"/><references/>
+
__TOC__
-
[[Category: Bracher, A.]]
+
</StructureSection>
-
[[Category: Li, Z.]]
+
[[Category: Homo sapiens]]
-
[[Category: Actin-like fold]]
+
[[Category: Large Structures]]
-
[[Category: Chaperone]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Cytosol]]
+
[[Category: Bracher A]]
-
[[Category: Molecular chaperone complex]]
+
[[Category: Li Z]]
-
[[Category: Nucleotide binding domain]]
+
-
[[Category: Solenoid]]
+
-
[[Category: Tetratricopeptide repeat]]
+

Current revision

Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip

PDB ID 4j8f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4j8f"
Personal tools