This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4c2v
From Proteopedia
(Difference between revisions)
m (Protected "4c2v" [edit=sysop:move=sysop]) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Aurora B kinase in complex with the specific inhibitor Barasertib== | |
| + | <StructureSection load='4c2v' size='340' side='right'caption='[[4c2v]], [[Resolution|resolution]] 1.49Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4c2v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2V FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=YJA:2-[5-[[7-[3-[ETHYL(2-HYDROXYETHYL)AMINO]PROPOXY]QUINAZOLIN-4-YL]AMINO]-1H-PYRAZOL-3-YL]-N-(3-FLUOROPHENYL)ETHANAMIDE'>YJA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2v OCA], [https://pdbe.org/4c2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2v RCSB], [https://www.ebi.ac.uk/pdbsum/4c2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/AUKBA_XENLA AUKBA_XENLA]] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Phosphorylates 'Ser-10' of histone H3 during mitosis.<ref>PMID:12221116</ref> <ref>PMID:11350965</ref> <ref>PMID:17199039</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Sessa F]] | ||
| + | [[Category: Villa F]] | ||
Current revision
Aurora B kinase in complex with the specific inhibitor Barasertib
| |||||||||||
