4m0l

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{{STRUCTURE_4m0l| PDB=4m0l | SCENE= }}
 
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===Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus complexed with GDP===
 
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==Function==
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==Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus complexed with GDP==
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[[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
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<StructureSection load='4m0l' size='340' side='right'caption='[[4m0l]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4m0l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3p3m 3p3m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M0L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m0l OCA], [https://pdbe.org/4m0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m0l RCSB], [https://www.ebi.ac.uk/pdbsum/4m0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m0l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF2G_SACS2 IF2G_SACS2] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.[HAMAP-Rule:MF_00119]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In eukaryotes and archaea, the heterotrimeric translation initiation factor 2 (e/aIF2) is pivotal for the delivery of methionylated initiator tRNA (Met-tRNA(i)) to the ribosome. It acts as a molecular switch that cycles between inactive (GDP-bound) and active (GTP-bound) states. Recent studies show that eIF2 can also exist in a long-lived eIF2gamma-GDP-P(i) (inorganic phosphate) active state. Here, four high-resolution crystal structures of aIF2gamma from Sulfolobus solfataricus are reported: aIF2gamma-GDPCP (a nonhydrolyzable GTP analogue), aIF2gamma-GDP-formate (in which a formate ion possibly mimics P(i)), aIF2gamma-GDP and nucleotide-free aIF2gamma. The structures describe the different states of aIF2gamma and demonstrate the conformational transitions that take place in the aIF2gamma `life cycle'.
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==About this Structure==
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Conformational transitions in the gamma subunit of the archaeal translation initiation factor 2.,Nikonov O, Stolboushkina E, Arkhipova V, Kravchenko O, Nikonov S, Garber M Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):658-67. doi:, 10.1107/S1399004713032240. Epub 2014 Feb 15. PMID:24598735<ref>PMID:24598735</ref>
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[[4m0l]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3p3m 3p3m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0L OCA].
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[[Category: Sulfolobus solfataricus p2]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Arkhipova, V I.]]
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</div>
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[[Category: Gabdulkhakov, A G.]]
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<div class="pdbe-citations 4m0l" style="background-color:#fffaf0;"></div>
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[[Category: Garber, M B.]]
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== References ==
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[[Category: Lazopulo, A M.]]
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<references/>
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[[Category: Lazopulo, S M.]]
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__TOC__
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[[Category: Nikonov, O S.]]
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</StructureSection>
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[[Category: Nikonov, S V.]]
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[[Category: Large Structures]]
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[[Category: Nikulin, A D.]]
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[[Category: Saccharolobus solfataricus P2]]
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[[Category: Stolboushkina, E A.]]
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[[Category: Arkhipova VI]]
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[[Category: Aif2]]
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[[Category: Gabdulkhakov AG]]
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[[Category: Aif2 gamma subunit]]
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[[Category: Garber MB]]
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[[Category: G-protein]]
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[[Category: Lazopulo AM]]
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[[Category: Gtp-binding]]
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[[Category: Lazopulo SM]]
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[[Category: Nucleotide-binding]]
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[[Category: Nikonov OS]]
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[[Category: Protein biosynthesis]]
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[[Category: Nikonov SV]]
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[[Category: Rna-binding]]
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[[Category: Nikulin AD]]
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[[Category: Translation]]
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[[Category: Stolboushkina EA]]
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[[Category: Translation initiation]]
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Current revision

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus complexed with GDP

PDB ID 4m0l

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