4jfi

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{{STRUCTURE_4jfi| PDB=4jfi | SCENE= }}
 
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===Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione===
 
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{{ABSTRACT_PUBMED_23647266}}
 
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==Function==
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==Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione==
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[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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<StructureSection load='4jfi' size='340' side='right'caption='[[4jfi]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JFI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KT:1-[(9S,13R,13AR)-1,3-DIMETHOXY-8-OXO-5,8,9,10,11,12,13,13A-OCTAHYDRO-6H-9,13-EPIMINOAZOCINO[2,1-A]ISOQUINOLIN-14-YL]-2-(3,4,5-TRIMETHOXYPHENYL)ETHANE-1,2-DIONE'>1KT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jfi OCA], [https://pdbe.org/4jfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jfi RCSB], [https://www.ebi.ac.uk/pdbsum/4jfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jfi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
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==About this Structure==
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==See Also==
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[[4jfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFI OCA].
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023647266</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Bracher, A.]]
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[[Category: Bracher A]]
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[[Category: Fabian, A.]]
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[[Category: Fabian A]]
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[[Category: Gopalakrishnan, R.]]
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[[Category: Gopalakrishnan R]]
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[[Category: Hausch, F.]]
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[[Category: Hausch F]]
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[[Category: Hoogeland, B.]]
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[[Category: Hoogeland B]]
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[[Category: Kirschner, A.]]
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[[Category: Kirschner A]]
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[[Category: Koch, U.]]
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[[Category: Koch U]]
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[[Category: Kozany, C.]]
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[[Category: Kozany C]]
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[[Category: Kress, C.]]
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[[Category: Kress C]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Fk-506 binding domain]]
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[[Category: Hsp90 cochaperone]]
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[[Category: Immunophiline]]
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[[Category: Isomerase]]
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[[Category: Peptidyl-prolyl isomerase]]
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Current revision

Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione

PDB ID 4jfi

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