4lh0

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{{STRUCTURE_4lh0| PDB=4lh0 | SCENE= }}
 
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===Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with glyoxylate===
 
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{{ABSTRACT_PUBMED_23928095}}
 
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==Function==
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==Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with glyoxylate==
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[[http://www.uniprot.org/uniprot/AL4A1_MOUSE AL4A1_MOUSE]] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).
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<StructureSection load='4lh0' size='340' side='right'caption='[[4lh0]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4lh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LH0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.674&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lh0 OCA], [https://pdbe.org/4lh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lh0 RCSB], [https://www.ebi.ac.uk/pdbsum/4lh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lh0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AL4A1_MOUSE AL4A1_MOUSE] Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity).
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==About this Structure==
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==See Also==
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[[4lh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH0 OCA].
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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*[[Pyrroline-5-carboxylate dehydrogenase|Pyrroline-5-carboxylate dehydrogenase]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:023928095</ref><references group="xtra"/><references/>
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</StructureSection>
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[[Category: 1-pyrroline-5-carboxylate dehydrogenase]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Pemberton, T A.]]
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[[Category: Pemberton TA]]
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[[Category: Tanner, J J.]]
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[[Category: Tanner JJ]]
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[[Category: Oxidoreductase]]
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[[Category: Proline catabolism]]
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[[Category: Rossmann fold]]
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[[Category: Substrate recognition]]
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Current revision

Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with glyoxylate

PDB ID 4lh0

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