4aur

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{{STRUCTURE_4aur| PDB=4aur | SCENE= }}
 
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===LeoA bacterial dynamin GTPase from ETEC===
 
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==About this Structure==
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==LeoA bacterial dynamin GTPase from ETEC==
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[[4aur]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_etec_h10407 Escherichia coli etec h10407]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUR OCA].
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<StructureSection load='4aur' size='340' side='right'caption='[[4aur]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Escherichia coli etec h10407]]
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== Structural highlights ==
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[[Category: Low, H H.]]
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<table><tr><td colspan='2'>[[4aur]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_ETEC_H10407 Escherichia coli ETEC H10407]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AUR FirstGlance]. <br>
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[[Category: Lowe, J.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Michie, K A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Hydrolase]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aur OCA], [https://pdbe.org/4aur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aur RCSB], [https://www.ebi.ac.uk/pdbsum/4aur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aur ProSAT]</span></td></tr>
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[[Category: Lt toxin]]
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion. By sequence comparisons and X-ray structure determination we now identify LeoA as a bacterial dynamin-like protein (DLP). Proteins of the dynamin family remodel membranes and were once thought to be restricted to eukaryotes. In ETEC H10407 LeoA localises to the periplasm where it forms a punctate localisation pattern. Bioinformatic analyses of leoA and the two upstream genes leoB and leoC suggest that LeoA works in concert with a second dynamin-like protein, made up of LeoB and LeoC. Disruption of the leoAB genes leads to a reduction in secretion of periplasmic Tat-GFP and outer membrane OmpA. Our data suggest a role for LeoABC dynamin-like proteins in potentiating virulence through membrane vesicle associated toxin secretion.
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LeoA, B and C from Enterotoxigenic Escherichia coli (ETEC) Are Bacterial Dynamins.,Michie KA, Boysen A, Low HH, Moller-Jensen J, Lowe J PLoS One. 2014 Sep 9;9(9):e107211. doi: 10.1371/journal.pone.0107211. eCollection, 2014. PMID:25203511<ref>PMID:25203511</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4aur" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli ETEC H10407]]
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[[Category: Large Structures]]
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[[Category: Low HH]]
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[[Category: Lowe J]]
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[[Category: Michie KA]]

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LeoA bacterial dynamin GTPase from ETEC

PDB ID 4aur

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