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4m55

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{{STRUCTURE_4m55| PDB=4m55 | SCENE= }}
 
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===Crystal structure of Human UDP-xylose synthase R236H substitution===
 
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==Function==
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==Crystal structure of Human UDP-xylose synthase R236H substitution==
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[[http://www.uniprot.org/uniprot/UXS1_HUMAN UXS1_HUMAN]] Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
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<StructureSection load='4m55' size='340' side='right'caption='[[4m55]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4m55]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M55 FirstGlance]. <br>
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[[4m55]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M55 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m55 OCA], [https://pdbe.org/4m55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m55 RCSB], [https://www.ebi.ac.uk/pdbsum/4m55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m55 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UXS1_HUMAN UXS1_HUMAN] Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: UDP-glucuronate decarboxylase]]
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[[Category: Large Structures]]
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[[Category: Polizzi, S J.]]
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[[Category: Polizzi SJ]]
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[[Category: Walsh, R M.]]
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[[Category: Walsh Jr RM]]
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[[Category: Wood, Z A.]]
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[[Category: Wood ZA]]
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[[Category: Decarboxylase]]
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[[Category: Lyase]]
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[[Category: Membrane]]
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[[Category: Rossman fold]]
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[[Category: Short-chain dehydrogenase/reductase]]
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Current revision

Crystal structure of Human UDP-xylose synthase R236H substitution

PDB ID 4m55

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