3pzd

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{{STRUCTURE_3pzd| PDB=3pzd | SCENE= }}
 
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===Structure of the myosin X MyTH4-FERM/DCC complex===
 
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{{ABSTRACT_PUBMED_21321230}}
 
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==Function==
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==Structure of the myosin X MyTH4-FERM/DCC complex==
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[[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref> [[http://www.uniprot.org/uniprot/DCC_MOUSE DCC_MOUSE]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
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<StructureSection load='3pzd' size='340' side='right'caption='[[3pzd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3pzd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZD FirstGlance]. <br>
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[[3pzd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZD OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pzd OCA], [https://pdbe.org/3pzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pzd RCSB], [https://www.ebi.ac.uk/pdbsum/3pzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pzd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref>
==See Also==
==See Also==
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*[[Myosin|Myosin]]
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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*[[Netrin receptor|Netrin receptor]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:021321230</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Pan, L.]]
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[[Category: Pan L]]
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[[Category: Wei, Z.]]
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[[Category: Wei Z]]
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[[Category: Yan, J.]]
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[[Category: Yan J]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Cargo binding]]
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[[Category: Ferm domain]]
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[[Category: Motor protein-apoptosis complex]]
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[[Category: Myth4 domain]]
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[[Category: Protein-protein complex]]
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Current revision

Structure of the myosin X MyTH4-FERM/DCC complex

PDB ID 3pzd

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