3u6w

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{{STRUCTURE_3u6w| PDB=3u6w | SCENE= }}
 
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===Truncated M. tuberculosis LeuA (1-425) complexed with KIV===
 
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{{ABSTRACT_PUBMED_22352945}}
 
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==Function==
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==Truncated M. tuberculosis LeuA (1-425) complexed with KIV==
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[[http://www.uniprot.org/uniprot/LEU1_MYCTU LEU1_MYCTU]] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
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<StructureSection load='3u6w' size='340' side='right'caption='[[3u6w]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U6W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KIV:3-METHYL-2-OXOBUTANOIC+ACID'>KIV</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u6w OCA], [https://pdbe.org/3u6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u6w RCSB], [https://www.ebi.ac.uk/pdbsum/3u6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u6w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEU1_MYCTU LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
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==About this Structure==
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==See Also==
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[[3u6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U6W OCA].
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*[[2-isopropylmalate synthase 3D structures|2-isopropylmalate synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022352945</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: 2-isopropylmalate synthase]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Mycobacterium tuberculosis h37rv]]
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[[Category: Baker EN]]
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[[Category: Baker, E N.]]
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[[Category: Koon N]]
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[[Category: Koon, N.]]
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[[Category: Squire CJ]]
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[[Category: Squire, C J.]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Truncated M. tuberculosis LeuA (1-425) complexed with KIV

PDB ID 3u6w

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