4gne
From Proteopedia
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| - | {{STRUCTURE_4gne| PDB=4gne | SCENE= }} | ||
| - | ===Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7=== | ||
| - | {{ABSTRACT_PUBMED_23269674}} | ||
| - | == | + | ==Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7== |
| - | [[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN | + | <StructureSection load='4gne' size='340' side='right'caption='[[4gne]], [[Resolution|resolution]] 1.47Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GNE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gne OCA], [https://pdbe.org/4gne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gne RCSB], [https://www.ebi.ac.uk/pdbsum/4gne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gne ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: He | + | [[Category: Large Structures]] |
| - | [[Category: Li | + | [[Category: He C]] |
| - | [[Category: Shi | + | [[Category: Li F]] |
| - | [[Category: Wu | + | [[Category: Shi Y]] |
| - | + | [[Category: Wu J]] | |
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Current revision
Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-7
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Categories: Homo sapiens | Large Structures | He C | Li F | Shi Y | Wu J
