4gnk

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{{STRUCTURE_4gnk| PDB=4gnk | SCENE= }}
 
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===Crystal structure of Galphaq in complex with full-length human PLCbeta3===
 
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{{ABSTRACT_PUBMED_23377541}}
 
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==Function==
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==Crystal structure of Galphaq in complex with full-length human PLCbeta3==
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[[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/PLCB3_HUMAN PLCB3_HUMAN]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
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<StructureSection load='4gnk' size='340' side='right'caption='[[4gnk]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gnk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GNK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnk OCA], [https://pdbe.org/4gnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gnk RCSB], [https://www.ebi.ac.uk/pdbsum/4gnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref>
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==About this Structure==
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==See Also==
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[[4gnk]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GNK OCA].
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*[[Phospholipase C|Phospholipase C]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023377541</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Phosphoinositide phospholipase C]]
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[[Category: Lyon AM]]
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[[Category: Lyon, A M.]]
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[[Category: Tesmer JJG]]
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[[Category: Tesmer, J J.G.]]
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[[Category: C2 domain]]
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[[Category: Calcium binding]]
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[[Category: Coiled-coil domain]]
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[[Category: Ef hand]]
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[[Category: G-protein signaling]]
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[[Category: Gtp binding]]
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[[Category: Gtp hydrolysis]]
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[[Category: Gtp-binding protein alpha subunit]]
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[[Category: Gtp-binding protein-hydrolase complex]]
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[[Category: Hydrolase]]
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[[Category: Lipase]]
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[[Category: Membrane targeting]]
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[[Category: Ph domain]]
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[[Category: Phospholipase]]
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[[Category: Phospholipase c beta]]
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[[Category: Phospholipid]]
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[[Category: Tim barrel domain]]
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Current revision

Crystal structure of Galphaq in complex with full-length human PLCbeta3

PDB ID 4gnk

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